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Diagnosis and Management of Neurological Sarcoidosis Arch Int Med 157:1864-1868, Lower,E.E.,et al, 1997 See this aricle in Pubmed Article Abstract Neurological disease was identified in 71 of 554 patients with sarcoidosis.Seventh(facial)cranial nerve paralysis was the most common manifestation identified in 39 patients.This included 24 patients with facial nerve palsy as the only manifestation of neurological sarcoidosis in whom complete recovery was seen in all but 1 patient.Forty-eight patients with disease other than facial nerve palsy received corticosteroids or other therapies.Corticosteroids benefited only 14 patients(29%).Methotrexate successfully treated 17(61%)of 28 patients and cyclophosphamide controlled disease in 9(90%)of 10 assessable patients. Methotrexate and cyclophosphamide were each associated with a higher response rate than corticosteroids alone(x squared,14.6;P<.001). Neurological symptoms can be significantly manifestations of sarcoidosis. Facial nerve paralysis is a common,but usually self-limited form of disease.Other manifestations are usually chronic and agents other than corticosteroids appear to have increased efficacy with lower morbidity.

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(click to filter results - removes previous filter) cyclophosphamide facial nerve palsy immunosuppressive agents methotrexate neurologic disease,diagnoses of prognosis review article sarcoidosis sarcoidosis,CNS steroid therapy,CNS treatment and complications with treatment of neurologic disorder

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